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Dynamics of growth of E. coli resistance to ciprofloxacin in the urine in the Republic of Buryatia in patients with complicated urinary tract infections

Dambaev A.   (Buryat State University, Ulan-Ude, Russia, Railways Clinical Hospital at the Station of Ulan-Ude of Russian Railways, Ulan-Ude, Russia)

Plekhanov A.   (Buryat State University, Ulan-Ude, Russia, Railways Clinical Hospital at the Station of Ulan-Ude of Russian Railways, Ulan-Ude, Russia)

Burasova E.   (Republican Clinical Hospital named after NA Semashko Ulan-Ude, Russia)

The aim of the study was to study resistance of E. coli to antibiotics in patients with complicated diseases of the genitourinary system in Ulan-Ude. The raw material was urine of patients, 687 Conducted bacteriological research in the period from 2009 to 2013, by sector Method of sowing, followed by antibiotikogramma. Complicated urinary tract infection (urinary tract infections) is an infection resulting from structural or functional disorders of the IMP, or on the background of concomitant diseases affecting the defense mechanisms of the microorganism and increase the risk of developing an infection or treatment failure. Complicated urinary tract infections may be caused by a wide spectrum of microorganisms. This range is much wider than in uncomplicated urinary tract infections, there is a higher likelihood that pathogens are resistant to antibiotics, especially in complicated urinary tract infections associated with treatment. The leading causative agents for complicated urinary tract infections are enterobacteria, among which the 1st place of E. coli (Escherichia coli). So it has become a subject of study. The result was the analysis of antibiotic resistance of Escherichia coli in the five years from 2009-2013, the Work showed an increase in the proportion of E. coli in the urine and an increase in resistance to Ciprofloxacin. Studies have shown that the mechanisms of antibiotic resistance associated with molecular-genetic processes in the cell. Conclusions: Ciprofloxacin cannot be recommended as empiric drug, due to the high percentage of resistance of E. coli. Increase side effects of antimicrobial therapy, dictate the need for alternative methods to combat diseases of the genitourinary system. The most promising, in our account, is a combination of herbal remedies and antibiotic therapy.

Keywords:E.coli, fluorinated quinolones, resistance, antibiotics.
 

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Citation link:
Dambaev A. , Plekhanov A. , Burasova E. Dynamics of growth of E. coli resistance to ciprofloxacin in the urine in the Republic of Buryatia in patients with complicated urinary tract infections // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2016. -№05. -С. 70-73
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