Ibragimova Kh. I. (Dagestan State Medical University, Dagestan, Makhachkala)
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Aim. Determine the level of endothelin-1 (ET-1) in the blood serum of patients with arterial hypertension (AH) according to gender and age.
Material and methods. The study involved 89 patients with essential hypertension. Patients were divided into 4 groups: women under the age of 50 years (group 1), with no symptoms of menopause, postmenopausal women older than 50 years (group 2), men under the age of 50 years (group 3), men older than 50 years (4 Group). The control group consisted of 35 healthy subjects, aged 19 to 49 years. To assess the functional status of the endothelium was determined by the level of endothelial vasoactive factors in serum ET-1 by enzyme immunoassay. Ambulatory blood pressure monitoring (ABPM) performed "Valenta" device.
Results. A significant increase in ET-1 levels in serum of patients with hypertension compared to healthy people. The highest concentration levels of ET-1 was detected in patients with hypertension in the group of women in menopause. In addition, significant correlation was found between serum levels of ET-1, both with an average daily value of systolic blood pressure (BP), and the average value of pulse pressure (PAP) in the group of women in menopause.
Conclusion. Our results suggest that endothelin is one of the most powerful vasoconstrictor factors contribute to the development of hypertension in menopausal women.
Keywords:arterial hypertension; gender differences; endothelial dysfunction.
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Citation link:
Ibragimova K. I. Endothelial function in patients with essential hypertension according to gender // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2016. -№12. -С. 76-79 |
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