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Features of ischemic heart disease etiology, pathogenesis, and clinical finding for women of reproductive age

Osikov M.   (FSBEI HE "South-Ural State Medical University" of the Ministry of Healthcare of the Russian Federation (Chelyabinsk))

Dolgushina A.   (FSBEI HE "South-Ural State Medical University" of the Ministry of Healthcare of the Russian Federation (Chelyabinsk))

Cherepenin S.   (FSBEI HE "South-Ural State Medical University" of the Ministry of Healthcare of the Russian Federation (Chelyabinsk); SBHI "Chelyabinsk Regional Clinical Hospital")

Research is devoted to the analysis of Russian Science Citation Index, Pubmed, and Medline data, from 2007 to 2017, and dedicated to peculiarities of etiology, pathogenesis and clinical finding of ischemic heart disease (IHD) for women of reproductive age (WRA) - 18-45 years. Found that the most significant risk factors for IHD for WRA are smoke, AH, diabetes type 2, complicated obstetric history, gynaecological diseases, hypestrogenism, hypotestosteronemia. Leading factors in the pathogenesis of IHD of WRA are particularities of pathomorphism of atherosclerotic plaque, anatomy of the epicardial coronary arteries, endothelial dysfunction, hyperreactivity and stenosis of the coronary arteries, thrombophilia. IHD clinical finding of WRA is charterized by atypicality of symptoms on localization, intensity, and physical activity. Promising studies for IHD of WRA seems to be further exploration of role of hormonal status, indicators of hemostasis, lipid metabolism, and endothelial function in etiology and pathogenesis. It will anable to develop effective and improve existing diagnostic, preventive and therapeutic strategies.

Keywords:ischemic heart disease (IHD), etiology, pathogenesis, women of reproductive age (WRA).

 

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Citation link:
Osikov M. , Dolgushina A. , Cherepenin S. Features of ischemic heart disease etiology, pathogenesis, and clinical finding for women of reproductive age // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2017. -№10. -С. 79-83
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