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Localization of serotonin and its membrane transporter in the mouse ovaries

Nikishin Denis Aleksandrovich  (Ph.D., Koltsov Institute of Developmental Biology RAS, Lomonosov Moscow State University )

Alyoshina Nina Maksimovna  (Lomonosov Moscow State University)

Semenova Maria Lvovna  (Doctor of biological sciences, Prof. Lomonosov Moscow State University )

Shmukler Yuri Borisovich  (Doctor of biological sciences, Leading Researcher, Koltsov Institute of Developmental Biology RAS )

Serotonin uptake by the membrane transporter Sert is a possible mechanism for the accumulation of the transmitter in oocytes and ovarian tissues. Serotonin is localized in developing ovarian follicles, and in a larger concentration is contained in oocytes. The content of the transmitter increases with the preliminary subcutaneous administration of exogenous serotonin. The expression of serotonin transporter Sert mRNA is detected in ovarian follicles, especially in granulosa cells. Sert represented in cells of the developing ovarian follicle, and detected in the oocytes to a greater extent. The obtained results indicate the presence and functional activity of the serotonin transporter in developing ovarian follicles.

Keywords:ovary, ovarian follicle, oocyte, serotonin, serotonin transporter, Sert
 

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Citation link:
Nikishin D. A., Alyoshina N. M., Semenova M. L., Shmukler Y. B. Localization of serotonin and its membrane transporter in the mouse ovaries // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2017. -№11. -С. 22-25
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