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The comparative analysis of the immunological indicators activating and inhibiting fibrosis at patients with localized scleroderma and systemic sclerosis

Mylnikova O.   (Federal State-funded Educational Institution of the Higher Education Orenburgsky State Medical University of the Russian Ministry of Health)

Kozlova L.   (Federal State-funded Educational Institution of the Higher Education Orenburgsky State Medical University of the Russian Ministry of Health)

Voronina L.   (Federal State-funded Educational Institution of the Higher Education Orenburgsky State Medical University of the Russian Ministry of Health)

Smolyagin A.   (Federal State-funded Educational Institution of the Higher Education Orenburgsky State Medical University of the Russian Ministry of Health)

Popova E.   (St. Joseph University, Tanzania)

Results of a research of content of interleukin-6 (IL-6), interferon – gamma (IN-gamma) and a fibroblast growth factor basic (FGF2) in serum of blood of patients of localized scleroderma (LS) and systemic sclerosis (SS) are presented in article. Correlation communication between the size FGF2, quantity of the centers of damage of skin and level of anti-nuclear antibodies and antibodies to Scl-70 antigen and also his significant increase at a stage of an induration and an atrophy of skin at patients with LS is revealed. The research of the IL-6 level and IN-gamma at both diseases hasn't revealed essential changes.

Keywords:skleroderma, interleukin-6, interferon-gamma, fibroblast growth factor basic.

 

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Citation link:
Mylnikova O. , Kozlova L. , Voronina L. , Smolyagin A. , Popova E. The comparative analysis of the immunological indicators activating and inhibiting fibrosis at patients with localized scleroderma and systemic sclerosis // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2017. -№12. -С. 97-102
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