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About the pathogenetic and clinical significance of antigenspecific B-cell activation in early rheumatoid arthritis

Mamasaidov Abdimutalib Tashalievich  (doctor of medical sciences, professor, Osh State University)

Eshbayeva Chynara Abdasbekovna  (Lecturer, Osh State University)

Kalmatov Romanbek Kalmatovich  (doctor of medical sciences, Professor, Osh State University)

In this paper, the pathogenetic and clinical significance of antigen - specific B - cell activation in early rheumatoid arthritis (RA) is considered. It is assumed that the cause of immunopathological reactions is a violation of the regulation of the immune response, resulting from an imbalance in the function of T and B lymphocytes, namely the immunodeficiency of the T-lymphocyte system, which leads to uncontrolled synthesis of B-lymphocytes of antibodies, in particular IgG. The existence of collagen sensitive B cells in early RA suggests that in addition to the presence of appropriate antibodies, the ability of lymphocyte cultures to spontaneously produce antibodies to collagen II in early RA [1] and collagen induced arthritis, an increase in the proliferative response to cartilage proteoglycans. In the study of supernatant of short-term cultures of peripheral lymphocytes, the presence in the population of autoantibody-forming cells with selective metabolic activity in the connective tissue structures of the synovial membrane in early RA [1] was shown, and the proliferation of B cells in the presence of synovial cells in patients with early RA was enhanced.

Keywords:early rheumatoid arthritis, rheumatoid factor, T-lymphocytes, B-lymphocytes, immunoglobulin G, immunoglobulin M, cartilage
 

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Citation link:
Mamasaidov A. T., Eshbayeva C. A., Kalmatov R. K. About the pathogenetic and clinical significance of antigenspecific B-cell activation in early rheumatoid arthritis // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2018. -№10. -С. 79-82
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