Semelev Viacheslav (candidate of medical sciences, associate professor of the chair, Military – Medical Academy C.M. Kirov)
Tyrenko Vadim (doctor of medical sciences, head of the chair, Military – Medical Academy C.M. Kirov )
Yurkin Alexander (candidate of medical sciences, assistant of the chair, Military – Medical Academy C.M. Kirov)
Tarakanova Lyubov (haematologist, Military – Medical Academy C.M. Kirov)
Nikitin Vladimir (doctor of medical sciences, head of immunological laboratory, Military – Medical Academy C.M. Kirov)
Sukhina Irina (candidate of medical sciences, head of laboratory, Military – Medical Academy C.M. Kirov)
Egorova Elizaveta (candidate of medical sciences, head of laboratory, Military – Medical Academy C.M. Kirov)
Voloshin Sergey (candidate of medical sciences, head of clinical department Russian Research Institute of Hematology and Transfusiology)
Uspenskaya Olga (candidate of medical sciences, head of the division, Leningrad regional Clinical, St. Petersburg)
Karyagina Elena (head of the division, City Hospital No. 15, St. Petersburg)
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The highest incidence of hemorrhagic complications in patients with AML younger than 60 years was found during the initial attack of the disease, induction and consolidation cycles, as well as with the recurrence of the disease with a tendency to decrease during the maintenance therapy and the level of the control group during the follow-up. At the same time, the highest frequency of hemorrhagic complications of grade III and IV was observed at the stages of the primary attack of the disease, during the induction and consolidation cycles, as well as during the recurrence of the disease. The use of hemostasis indicators in a diagnostic model as a set of linear classification functions makes it possible to single out a risk of developing hemorrhagic complications Grade III and IV complications in AML patients younger than 60 years of age and is a highly sensitive informative method for predicting the development of complications before the next therapeutic stage or at the observation stages.
Keywords:acute myeloid leukemia, hemostasis indicators, hemorrhagic complications, 5-years overall survival.
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Citation link:
Semelev V. , Tyrenko V. , Yurkin A. , Tarakanova L. , Nikitin V. , Sukhina I. , Egorova E. , Voloshin S. , Uspenskaya O. , Karyagina E. Hemorrhagic complications in patients with acute myeloid leukemia younger 60 years and their prediction by hemostasis indicators // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2019. -№1. -С. 117-123 |
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