Dumchenko Natalya Borisovna (Federal State Budgetary Institution "State Scientific Center of Virology and Biotechnology" Vector "Rospotrebnadzor, Koltsovo, Novosibirsk Region, Russia)
Nechaeva Elena Avgustovna (Federal State Budgetary Institution "State Scientific Center of Virology and Biotechnology" Vector "Rospotrebnadzor, Koltsovo, Novosibirsk Region, Russia)
Radaeva Irina Fedorovna (Federal State Budgetary Institution "State Scientific Center of Virology and Biotechnology" Vector "Rospotrebnadzor, Koltsovo, Novosibirsk Region, Russia)
Rudenko Larisa Georgievna (Federal State Budgetary Institution "State Scientific Center of Virology and Biotechnology" Vector "Rospotrebnadzor, Koltsovo, Novosibirsk Region, Russia)
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The composition of the nutrient media contains the serum of the fetus of animals. Serum, as a product of animal origin, remains an unexplored complex of various components, creates non-standard conditions for the growth and reproduction of cells and viruses. In addition, there are problems associated with the potential for serum contamination by bacteria, fungi, mycoplasmas, viruses, and causative agents of transmissible spongiform encephalopathy. When using serum, it is highly likely that pyrogens and residual serum elements will enter the final vaccine product. Therefore, the selection of hydrolysates for a specific cell culture is today one of the urgent problems of cell biotechnology.
Keywords:viruses, cells, growth media, hydrolysates, vaccines
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Citation link:
Dumchenko N. B., Nechaeva E. A., Radaeva I. F., Rudenko L. G. The use of various hydrolysates in the production of influenza vaccines // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2019. -№11-2. -С. 6-9 |
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