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Association of polymorphisms –262 C >T of CAT gene and G/A of PDE7B gene with the risk of male infertility

Myandina Galina Ivanovna  (Dr.Sc. (Biol.), professor, Peoples’ Friendship University of Russia)

Alhejoi Hasan   (post-graduate student, Peoples’ Friendship University of Russia)

Kulchenko Nina Gennadievna  (candidate of medical Sciences, doctor of urology, doctor of ultrasound diagnostics, senior lecturer, Peoples’ Friendship University of Russia)

the paper studies the effect of polymorphisms -262 C >T of cat catalase gene and g/a of pde7b phosphodiesterase gene on the development of pathospermia among infertile men in the Moscow region. Infertility affects 10-15% of couples worldwide and in 50% of cases is caused by fertility disorders in men [1]. Despite significant advances in reproductive technologies and diagnostic methods, the etiology of 50% of male infertility cases remains unknown. Since more than 2,300 genes are involved in spermatogenesis, polymorphisms in many as yet unidentified genes may affect sperm quality and male reproductive function. In this article, a study was conducted in which 138 men participated. During the study, a genetic analysis of DNA isolated from the peripheral blood leukocytes of infertile and fertile men was carried out. All DNA samples studied for the presence of polymorphisms using the methods of polymerase chain reaction (PCR) of DNA synthesis in real time (Real-Time-PCR). Ready-made sets for polymorphism determination were used for PCR ("Sintol" company).

Keywords:male infertility, genetic factor, gene CAT, PDE7B, polymorphism.
 

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Citation link:
Myandina G. I., Alhejoi H. , Kulchenko N. G. Association of polymorphisms –262 C >T of CAT gene and G/A of PDE7B gene with the risk of male infertility // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2019. -№3. -С. 37-41
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