Журнал «Современная Наука»

Russian (CIS)English (United Kingdom)
 MOSCOW +7(495)-142-86-81

Allelic variants of DRD2 and COMT genes and antipsychotic-induced hyperprolactinemia in patients with schizophrenia

Paderina Diana Zakirovna  (Post-graduate student, National Research Tomsk State University, employee, Mental Health Research Institute, Tomsk NRMC Russian Academy of Sciences, Tomsk)

Tiguntsev Vladimir Vladimirovich  (Researcher, Mental Health Research Institute, Tomsk NRMC Russian Academy of Sciences, Tomsk )

Stegniy Vladimir Nikolaevich  (Doctor of Biological Sciences, Professor, National Research Tomsk State University)

Hyperprolactinemia is a prevalent neuroendocrine side effect that occurs with pharmacotherapy of schizophrenia. The likelihood of developing hyperprolactinemia depends both on the pharmacological properties of the antipsychotic and on the individual sensitivity and genetic characteristics of the patient. The study examined the genes of the dopaminergic system, which can predict individual susceptibility to side effects caused by antipsychotics. It has been shown that the DRD2 and COMT genes are involved in the formation of the genetic component of the development of drug-induced hyperprolactinemia in patients with schizophrenia.

Keywords:genetics, pharmacogenetics, dopamine, COMT, schizophrenia, antipsychotics, hyperprolactinemia.
 

Read the full article …

Citation link:
Paderina D. Z., Tiguntsev V. V., Stegniy V. N. Allelic variants of DRD2 and COMT genes and antipsychotic-induced hyperprolactinemia in patients with schizophrenia // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2020. -№01. -С. 201-204
LEGAL INFORMATION:
Reproduction of materials is permitted only for non-commercial purposes with reference to the original publication. Protected by the laws of the Russian Federation. Any violations of the law are prosecuted.
© ООО "Научные технологии"

Terms Publications

Issues of the journals (Archive)

ECONOMICS AND LAW
HUMANITIES
NATURAL AND TECHNICAL SCIENCES
COGNITION

Серия - Natural and Technical Sciences