Журнал «Современная Наука»

Russian (CIS)English (United Kingdom)
 MOSCOW +7(495)-142-86-81

Endothelin — 1 gene Lys198Asn polymorphism and development of cardiovascular pathology (review)

Bebyakova Natalia Alexandrovna  (Northern state Мedical University (Arkhangelsk))

Levitsky Sergey Nikolaevich  (Northern state Мedical University (Arkhangelsk))

Shabalina Irina Alekseevna  (Northern state Мedical University (Arkhangelsk))

Sumarokova Alina Vladimirovna  (Northern state Мedical University (Arkhangelsk))

Kurochkina Ekaterina Leonidovna  (Northern state Мedical University (Arkhangelsk))

The article presents the generalized data of foreign and domestic literature on the influence of the candidate gene endothelin-1, responsible for the synthesis of the most powerful vasoconstrictor endothelin-1, as well as the possible influence of the polymorphic variant Lys198Asn on the development of cardiovascular diseases. The identified associations between lys198asn polymorphism in the endothelin-1 gene and changes in the functioning of the cardiovascular system, in particular, with myocardial infarction, various cardiomyopathies and other diseases, were studied. To date, it has been established that polymorphism of the endothelin-1 gene is not always associated with the risk of cardiovascular diseases, often the results of studies are contradictory, which requires further study of the role of lys198asn polymorphism in the endothelin-1 gene as a genetic marker of changes in the cardiovascular system.

Keywords:genetic markers of cardiovascular diseases, polymorphism of endothelin-1 gene.
 

Read the full article …

Citation link:
Bebyakova N. A., Levitsky S. N., Shabalina I. A., Sumarokova A. V., Kurochkina E. L. Endothelin — 1 gene Lys198Asn polymorphism and development of cardiovascular pathology (review) // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2020. -№03. -С. 12-16
LEGAL INFORMATION:
Reproduction of materials is permitted only for non-commercial purposes with reference to the original publication. Protected by the laws of the Russian Federation. Any violations of the law are prosecuted.
© ООО "Научные технологии"

Terms Publications

Issues of the journals (Archive)

ECONOMICS AND LAW
HUMANITIES
NATURAL AND TECHNICAL SCIENCES
COGNITION

Серия - Natural and Technical Sciences