Bokova Elizaveta Olegovna (Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University))
Vostrikova Sofya Mikhailovna (Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University))
Grinev Alexander Borisovich (c.b.s., Associate Professor, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University))
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Burkitt’s lymphoma (BL) is one of the most common pediatric cancers. The aim of the article is to review literature sources on the BL epidemiology, pathogenic mechanisms that determine the association of endemic BL with Epstein–Barr virus (EBV) infection and tropical malaria, and diagnostics of BL. The following tumor progression factors were identified as the key ones: T-lymphocyte dysfunction caused by P. falciparum invasion, inducting EBV reinfection, expression of activation-induced cytidine deaminase (AID) and c-myc oncogene translocation. Further scientific research of molecular-genetic mechanisms of BL progression is needed in order to develop new methods of early BL diagnostics.
Keywords:Burkitt’s lymphoma; endemic; Epstein-Barr virus; malaria; Plasmodium falciparum.
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Citation link:
Bokova E. O., Vostrikova S. M., Grinev A. B. Epidemiology and pathogenesis of Burkitt’s lymphoma: literature review // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2020. -№06. -С. 170-174 DOI 10.37882/2223-2966.2020.06.03 |
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