Pateyuk Andrey Vladimirovich (Doctor of Medical Sciences, Professor, Trans-Baikal State University, Chita)
Maksimenya Maria Vladimirovna (Ph.D., Senior Researcher, Research Institute of Molecular Medicine; Assistant, Chita State Medical Academy of the Ministry of Health of Russia, Chita)
Karavaeva Tatiana Mikhailovna (Candidate of Medical Sciences, Senior Researcher, Research Institute of Molecular Medicine; Associate Professor, Chita State Medical Academy of the Ministry of Health of Russia, Chita)
Bakalova Yulia Valerievna (Assistant, Chita State Medical Academy of the Ministry of Health of Russia, Chita)
Zhilyaeva Marianna Sergeevna (PhD in Psychology, Associate Professor, Trans-Baikal State University, Chita)
Tereshkov Pavel Petrovich (Ph.D., Research Institute of Molecular Medicine; Chita State Medical Academy of the Ministry of Health of Russia, Chita)
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One of the urgent problems of the modern world is the increase in patients with diabetes mellitus, leading to disability and death of people. Examination of 20 patients with type 1 diabetes mellitus without complications and 20 patients with diabetic cardiomyopathy was carried out. In the blood by HPLC, the concentrations of malondialdehyde (MDA), glyoxal (Go), methylglyoxal (MGo), glutathione (GSH) were determined; by ELISA the level of cytokines (IL-1β, IL-6, IL-10, IL-17, TNF-α) was assessed. In the presence of cardiomyopathy in persons of this category, the serum levels of glyoxal, methylglyoxal, interleukin-6, interleukin-10 and tumor necrosis factor -α are increased in the blood serum relative to individuals with diabetes without complications, and the values of free glutathione are decreased. These parameters can probably be used as diagnostic markers of heart damage in patients with type 1 diabetes mellitus.
Keywords:medical and social problem, type 1 diabetes mellitus, cardiomyopathy, oxidative stress, cytokines.
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Citation link:
Pateyuk A. V., Maksimenya M. V., Karavaeva T. M., Bakalova Y. V., Zhilyaeva M. S., Tereshkov P. P. Searching for new markers of the development of cardiomyopathy as a way to solving one of medical and social problems // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2020. -№08-2. -С. 81-86 DOI 10.37882/2223-2966.2020.08-2.12 |
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