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Anti-inflammatory effect of sodium-glucose cotransporter‑2 inhibitors (literature review)

Kolesnikov O. L.  (Doctor of Medical Sciences, Professor, FSBEI HE South-Urals State Medical University MOH Russia (Chelyabinsk))

Kolesnikova A. A.  (Ph.D. in Medical Sciences, Associate Professor, FSBEI HE South-Urals State Medical University MOH Russia (Chelyabinsk))

Tarabrina Iu. O.  (Ph.D. in Medical Sciences, Associate Professor, FSBEI HE South-Urals State Medical University MOH Russia (Chelyabinsk))

Sodium-glucose cotransporter type 2 inhibitors are a new class of antidiabetic drugs. These compounds inhibit the activity of the NLRP3 inflammasome. They also reduce the functional activity of immune system cells and the production of pro-inflammatory cytokines (TNF, IL-1, IL-6). These drugs reduce the expression of a number of genes associated with the development of inflammation. These effects indicate the presence of an anti-inflammatory effect in sodium-glucose cotransporter type 2 inhibitors.

Keywords:sodium-glucose cotransporter, inhibitor, inflammation, inflammasome, interleukin
 

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Citation link:
Kolesnikov O. L., Kolesnikova A. A., Tarabrina I. O. Anti-inflammatory effect of sodium-glucose cotransporter‑2 inhibitors (literature review) // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2021. -№09. -С. 120-124 DOI 10.37882/2223-2966.2021.09.15
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