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Markers of endothelial dysfunction in predicting the development of organ failure in patients with severe forms of erysipelas

Khaleev I. A.  (postgraduate, Saratov State Medical University)

Shapkin Yu. G.  (MD, professor, Saratov State Medical University)

Stekolnikov N. Y.  (Phd, Saratov State Medical University)

Seliverstov P. A.  (Phd, Saratov State Medical University)

The dynamics and prognostic significance of the plasma level of free vascular adhesion molecules sICAM-1, sVCAM-1, sE-selectin in patients with severe forms of erysipelas in comparison with the severity of systemic inflammation have been studied. It has been shown, that the levels of sE-selectin (Sp. 80.9%, Se. 51%, cr> 770ng / ml; p <0.05) and sVCAM-1 (Sp. 95.7%, Se. 93.1%, cr> 1398ng / ml p <0.0001) have significantly prognostic. Early determination of the level of these indicators can become a preclinical marker of the development of organ failure.

Keywords:sepsis, erysipelas, adhesion molecules, organ failure, endothelial dysfunction.
 

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Citation link:
Khaleev I. A., Shapkin Y. G., Stekolnikov N. Y., Seliverstov P. A. Markers of endothelial dysfunction in predicting the development of organ failure in patients with severe forms of erysipelas // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2021. -№11. -С. 215-221 DOI 10.37882/2223-2966.2021.11.38
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