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Sodium-glucose cotransporter inhibitors can positive affect the state of the brain

Kolesnikov O. L.  (Doctor of Science in Medical Sciences, Professor, FSBEI HE «South-Urals State Medical University» MOH Russia (Chelyabinsk))

Kolesnikova A. A.  (Ph.D. in Medical Sciences, Associate Professor, FSBEI HE «South-Urals State Medical University» MOH Russia (Chelyabinsk))

Tarabrina Iu. O.  (Ph.D. in Medical Sciences, Associate Professor, FSBEI HE «South-Urals State Medical University» MOH Russia (Chelyabinsk))

Sodium-glucose co-transporter inhibitors can reduce the severity of adverse changes occurring in cerebral ischemia. Drugs of this group attenuated cognitive impairment arising from diabetes mellitus. The neuroprotective effect of sodium-glucose transporter inhibitors has been demonstrated in models of Alzheimer's and Parkinson's diseases. Canagliflozin improved memory status with scopolamine administration. Possible mechanisms of neuroprotective effects are discussed.

Keywords:sodium-glucose cotransporter, inhibitor, brain, ischemia, cognitive impairment
 

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Citation link:
Kolesnikov O. L., Kolesnikova A. A., Tarabrina I. O. Sodium-glucose cotransporter inhibitors can positive affect the state of the brain // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2021. -№11. -С. 149-153 DOI 10.37882/2223-2966.2021.11.10
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