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Features of carbohydrate metabolism indicators and the content of receptors for the end products of glycation in pregnant women with alimentary obesity

Ryabov Alexey Yurievich  (Applicant, Samara State Medical University, Samara)

Ivanova Tatiana Vladimirovna  (Cand. honey. Sci., Associate Professor, Samara State Medical University, Samara)

Ilchenko Olesya Andreevna  (Post-graduate student, Samara State Medical University, Samara; doctor - obstetrician-gynecologist GBUZ SO SGP No. 3, Samara)

Trebunskikh Anna Sergeevna  (Applicant, Samara State Medical University, Samara; doctor - obstetrician-gynecologist GBUZ SO SGP No. 3, Samara)

The issues of the incidence of gestational diabetes mellitus (HDM), as well as subsequent perinatal and maternal complications, dictating the need to search for new early diagnostic criteria for the disease in order to determine the role of receptors for the end products of glycation in the development of gestational diabetes mellitus in women with moderate alimentary obesity are considered. A total of 214 pregnant women were examined in accordance with the current orders and recommendations of the Ministry of Health of the Russian Federation. SRAGE was determined by a quantitative enzyme-linked immunosorbent assay (automatic immunoanalyzer ChemWell® FUSION, USA). For the analysis, we used the Human RAGE Quantikine ELISA Kit (R&D Systems, USA). It was found that the average sRAGE content in women with GDM is statistically significantly higher than in patients without GDM.

Keywords:gestational diabetes mellitus, insulin resistance, receptors of glycation end products.
 

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Citation link:
Ryabov A. Y., Ivanova T. V., Ilchenko O. A., Trebunskikh A. S. Features of carbohydrate metabolism indicators and the content of receptors for the end products of glycation in pregnant women with alimentary obesity // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2022. -№01. -С. 196-201 DOI 10.37882/2223-2966.2022.01.29
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