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Analysis of single-nucleotide substitutions in TP53, HIF-1a genes in the formation of a predisposition to uncontrolled division of breast cells

Abdullina Victoria Viktorovna  (Federal State Budgetary Educational Institution of Higher Education "Bashkir State Pedagogical University named after M. Akmulla "(Ufa) )

Siham Mazouni   (Post-graduate student of the Federal State Budgetary Educational Institution of Higher Education "Bashkir State Pedagogical University named after M. Akmulla "(Ufa) )

Galimova Elvira Mansurovna  (Ph.D., Associate Professor of the Federal State Budgetary Educational Institution of Higher Education "Bashkir State Pedagogical University named after M. Akmulla "(Ufa) )

Galikeeva Guzel Fanilevna  (Ph.D., Associate Professor of the Federal State Budgetary Educational Institution of Higher Education "Bashkir State Pedagogical University named after M. Akmulla "(Ufa) )

The association of alleles and genotypes for the TP53 (rs1042522), HIF-1A (rs11549465) genes has been analyzed to identify risk groups with a predisposition to oncology, severe course due to the hypoxic factor.

Keywords:normoxia, hypoxia, breast cancer, tumor suppressor (TP53), hypoxia-inducible factor 1α (HIF-1A), missense mutation.
 

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Citation link:
Abdullina V. V., Siham M. , Galimova E. M., Galikeeva G. F. Analysis of single-nucleotide substitutions in TP53, HIF-1a genes in the formation of a predisposition to uncontrolled division of breast cells // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2022. -№03/2. -С. 5-7 DOI 10.37882/2223-2966.2022.03-2.01
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