Palyutina Elena Yurievna (Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics and Gynecology in Yaroslavl State Medical University, Ministry of Health of Russia)
Tikhomirova Svetlana Vladislavovna (Candidate of Biological Sciences, Associate Professor of the Department of Biology with Genetics in Yaroslavl State Medical University, Ministry of Health of Russia. Cytogeneticist of the State Budgetary Healthcare Institution of the Yaroslavl Region "Regional Perinatal Center")
Sotina Elena Mikhailovna (pathologist of the highest qualification category, head of the pathoanatomical department of the State Budgetary Institution of Healthcare of the Yaroslavl Region "Regional Perinatal Center")
Kozlovskaya Irina Alexandrovna (Candidate of Medical Sciences, obstetrician-gynecologist, State Budgetary Institution of Health of the Yaroslavl Region "Regional Perinatal Center")
| |
we have performed a retrospective analysis of anamnestic data of 64 patients with non-developing pregnancy between 6 and 12 weeks of gestation with the results of extension pathomorphological and cytogenetic study.
According to the results of a cytogenetic study, the chromosomal pathology has been detected in 45 (70.7%) samples. Prevailing types of disorders were trisomies 43.7% and triploidies 12.5%. According to the results of the extension pathomorphological study, the data on the chromosomal pathology have been detected in only 14 (20.3%) samples. The percentage of agreement is 33%. During the histologic study, the inflammatory process has been registered in 53% of cases. In this study pathological karyotype corresponded to a histologic pattern of inflammation in 38% of cases. In order to choose the right tactics of further treatment of patients with non-developing pregnancy, it is necessary to use at least 2 methods of study. Whenever possible they should be accompanied with molecular genetic and immunohistochemical diagnostic methods.
Keywords:non-developing pregnancy, cytogenetic study, morphological examination, karyotype.
|
|
| |
|
Read the full article …
|
Citation link:
Palyutina E. Y., Tikhomirova S. V., Sotina E. M., Kozlovskaya I. A. Comparative analysis of the causes of non-developing pregnancy – the view of obstetrician-gynecologist, pathomorphologist and cytogeneticist // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2022. -№09. -С. 218-223 DOI 10.37882/2223-2966.2022.09.27 |
|
|
