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Clinical and laboratory features of autoimmune gastritis in Siberia

Belkovets Anna Vladimirovna  (Doctor of Medical Sciences, Associate Professor, Senior Researcher, Laboratory of Gastroenterology, Research Institute of Therapy and Preventive Medicine - branch of the Federal State Budgetary Scientific Institution "Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences" MD, Prof. Department of propaedeutics of internal diseases Novosibirsk State Medical University)

Kruchinina Margarita Vitalievna  (Аssociate professor, Head of the Laboratory of Gastroenterology, Leading Researcher of the Laboratory of Gastroenterology, Doctor of Medical Sciences, Research Institute of Therapy and Preventive Medicine - branch of the Federal State Budgetary Scientific Institution "Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences" Professor of the Department of Propaedeutics of Internal Diseases Novosibirsk State Medical University)

Ozhiganova Natalya Vladimirovna  (Graduate student Research Institute of Therapy and Preventive Medicine - branch of the Federal State Budgetary Scientific Institution "Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences")

Shcherbakova Liliya Valerievna  (Senior Researcher, Laboratory of Clinical Population and Preventive Research on Therapeutic and Endocrine Diseases Research Institute of Therapy and Preventive Medicine - branch of the Federal State Budgetary Scientific Institution "Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences")

Autoimmune gastritis (AIG) is characterized by a low-symptomatic course (85.0%). More than half of the patients are diagnosed with autoimmune thyroiditis (AIT), anemia of various origins, latent deficiency of iron and vitamin B12. Patients with AIG in Siberia are often infected with Helicobacter pylori (H. pylori) (47%), and in half of the cases with a cytotoxic CagA + strain, with a more frequent development of anemia compared to H. pylori-negative patients with AIG (64.7% vs. 3%, p=0.02). The levels of atrophy biomarkers measured using two test systems ("GastroPanel" and "GastroScreen-3") for the serological diagnosis of the autoimmune phenotype of fundal atrophic gastritis were determined, with the identification of the closest associations for the indicators "GastroScreen-3". So, noninvasive diagnostics of AIG using biomarkers of atrophy, including the test system "GastroScreen-3", is promising for detecting the early stages of the disease, before the development of vitamin B12 deficiency and pernicious anemia.

Keywords:autoimmune gastritis, Helicobacter pylori, «GastroPanel», «GastroScreen-3», atrophy biomarkers, anemia.

 

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Citation link:
Belkovets A. V., Kruchinina M. V., Ozhiganova N. V., Shcherbakova L. V. Clinical and laboratory features of autoimmune gastritis in Siberia // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2022. -№12. -С. 116-121 DOI 10.37882/2223-2966.2022.12.03
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