Gumenyuk Lesya Nikolaevna (Doctor of Medical Sciences, Professor, Medical Academy named after S.I. Georgievsky (Academic Unit of Federal State Autonomous Educational Institution of Higher Education "V. I. Vernadsky Crimean Federal University"), Simferopol)
Aslalieva Madina Shamilovna (Student, Medical Academy named after S.I. Georgievsky (Academic Unit of Federal State Autonomous Educational Institution of Higher Education "V. I. Vernadsky Crimean Federal University"), Simferopol )
Abalduev Viktor Mikhailovich (Student, Medical Academy named after S.I. Georgievsky (Academic Unit of Federal State Autonomous Educational Institution of Higher Education "V. I. Vernadsky Crimean Federal University"), Simferopol)
Kopylova Alexandra Vladimirovna (Student, Medical Academy named after S.I. Georgievsky (Academic Unit of Federal State Autonomous Educational Institution of Higher Education "V. I. Vernadsky Crimean Federal University"), Simferopol )
Li Ekaterina (Student, Medical Academy named after S.I. Georgievsky (Academic Unit of Federal State Autonomous Educational Institution of Higher Education "V. I. Vernadsky Crimean Federal University"), Simferopol)
Khudyakova Anastasia Sergeevna (Student, Medical Academy named after S.I. Georgievsky (Academic Unit of Federal State Autonomous Educational Institution of Higher Education "V. I. Vernadsky Crimean Federal University"), Simferopol)
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Parkinson's disease (PD) is a severe socially significant progressive neurodegenerative disease. Evidence of a link between PD and the provision of the body with vitamin D is insufficient, which indicates the need for additional research in this direction. The aim of the study was to evaluate the association of vitamin D status in patients with PD with the clinical characteristics of the disease and the level of dopamine in the blood serum. The study involved 126 patients with idiopathic PD and 90 healthy volunteers (control group). Plasma levels of 25(OH)D and dopamine were assessed. It was found that in patients with PD, compared with the control, the level of 25(OH)D in the blood serum was statistically significantly lower. The association of the 25(OH)D level with the stage of the disease, the severity of non-motor and motor symptoms, the total UPDRS score, and the level of dopamine in the blood plasma was revealed. The data of this study provide additional evidence for a significant role of vitamin D in the pathophysiology of PD, which indicates the need for monitoring the level of 25 (OH)D in this population as a potential biomarker of disease progression.
Keywords:Parkinson's disease, vitamin D, motor and non-motor symptoms, dopamine.
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Citation link:
Gumenyuk L. N., Aslalieva M. S., Abalduev V. M., Kopylova A. V., Li E. , Khudyakova A. S. Vitamin D status in Parkinsons disese patients: assocuation with clinical features and dopamin // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2022. -№12. -С. 146-151 DOI 10.37882/2223-2966.2022.12.10 |
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