Lazareva Natalia Viktorovna (candidate of medical sciences,docent,
Orenburg State Medical University, Orenburg
Orenburg
)
Bugrova Olga Viktorovna (doctor of medical sciences, professor,
Orenburg State Medical University, Orenburg
)
Miroshnichenko Igor Vasilyevich ( doctor of medical sciences, professor, rector,
Orenburg State Medical University, Orenburg
)
Artemova Natalia Eduardovna (candidate of medical sciences, docent,
Orenburg State Medical University, Orenburg
)
Ivanov Konstantin Mikhailovich (doctor of medical sciences, professor,
Orenburg State Medical University, Orenburg
)
Nagornova Ksenia Aleksandrovna (candidate of medical sciences, docent,
North-Western State Medical University n
amed after I.I. Mechnikov, St. Petersburg
)
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Long-term inflammation in the vascular wall, in systemic autoimmune diseases, including systemic lupus erythematosus, is considered a decisive trigger of cardiovascular events due to changes in the functional activity of the endothelium and proliferation of vascular smooth muscle cells with their subsequent remodeling, leading to atherosclerosis. The aim of the study was to study the frequency and severity of changes in the functional activity of the endothelium as a sign of subclinical atherosclerosis in patients with lupus nephritis. 72 patients with systemic lupus erythematosus, mainly young women aged 36 (26; 47) years without clinical signs of atherosclerosis, were examined. Lupus nephritis was diagnosed in 65% of the examined patients. Population risk factors for cardiovascular diseases and laboratory parameters reflecting inflammatory vascular wall damage and endothelial dysfunction were evaluated. Population risk factors for cardiovascular diseases were significantly more common in patients with lupus nephritis. Endothelial dysfunction was detected in 83% of patients with lupus nephritis, and in 48% in the group without it. Thus, the severity of endothelial dysfunction was greatest in patients with lupus nephritis, compared with patients without it, despite the comparability of the lipid spectrum and other population risk factors. The severity of endothelial dysfunction is associated with the activity of systemic lupus erythematosus and severe organ damage, which is lupus nephritis. A significant increase in the biochemical marker, the von Willebrand factor, indicates deeper functional changes in the vascular wall, giving reason to assume further atherosclerotic lesions.
Keywords:atherosclerosis, lupus nephritis, endothelial dysfunction, systemic lupus erythematosus, risk factors
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Citation link:
Lazareva N. V., Bugrova O. V., Miroshnichenko I. V., Artemova N. E., Ivanov K. M., Nagornova K. A. CHANGES IN THE FUNCTIONAL ACTIVITY OF THE ENDOTHELIUM IN PATIENTS WITH LUPUS NEPHRITIS AS SIGNS OF SUBCLINICAL ATHEROSCLEROSIS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2023. -№01. -С. 194-199 DOI 10.37882/2223–2966.2023.01.23 |
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