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CELLULAR MECHANISMS OF FIBROSIS DEVELOPMENT

Karutskaya Olga Anatolyevna  (Graduate student Belgorod State National Research University )

Serdyukova Anna Viktorovna  (Graduate student, Belgorod State National Research University)

Brizhaneva Anastasia Sergeevna  (Graduate student Belgorod State National Research University )

Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic companion of many different myocardial conditions. Fibrosis may reflect activation of reparative or maladaptive processes. Activated fibroblasts and myofibroblasts are the central cellular effectors in cardiac fibrosis, serving as the main source of matrix proteins. Immune cells, vascular cells and cardiomyocytes may also acquire a fibrogenic phenotype under conditions of stress, activating fibroblast populations. Fibrogenic growth factors (such as transforming growth factor-β and platelet-derived growth factors), cytokines [including tumour necrosis factor-α, interleukin (IL)-1, IL-6, IL-10, and IL-4], and neurohumoral pathways trigger fibrogenic signalling cascades through binding to surface receptors, and activation of downstream signalling cascades. In addition, matricellular macromolecules are deposited in the remodelling myocardium and regulate matrix assembly, while modulating signal transduction cascades and protease or growth factor activity. Cardiac fibroblasts can also sense mechanical stress through mechanosensitive receptors, ion channels and integrins, activating intracellular fibrogenic cascades that contribute to fibrosis in response to pressure overload. Although subpopulations of fibroblast-like cells may exert important protective actions in both reparative and interstitial/perivascular fibrosis, ultimately fibrotic changes perturb systolic and diastolic function, and may play an important role in the pathogenesis of arrhythmias.

Keywords:Fibrosis, growth factor, heart failure, matrix metalloproteinases, chemokines.
 

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Citation link:
Karutskaya O. A., Serdyukova A. V., Brizhaneva A. S. CELLULAR MECHANISMS OF FIBROSIS DEVELOPMENT // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2023. -№02. -С. 193-201 DOI 10.37882/2223–2966.2023.02.17
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