Журнал «Современная Наука»

Russian (CIS)English (United Kingdom)
 MOSCOW +7(495)-142-86-81

GENES POLYMORPHISM AND ACUTE BRONCHITIS IN CHILDREN

Pikuza Ol'ga Ivanovna  (Dr. Sci. (Med.), Professor FGBEI HE “Kazan State Medical University”)

Rizvanova Farida Faritovna  (Cand. Sci. (Med.), Associate Professor FGAEI HE Kazan (Volga region) Federal University, Institute of Fundamental Medicine and Biology,)

Generalova Elena Vladimirovna  (Cand. Sci. (Med.), Associate Professor FGBEI HE “Kazan State Medical University” )

Kravcova Ol'ga Aleksandrovna  (Cand. Sci. (Biol.), Associate Professor FGBEI HE “Kazan State Medical University”)

Objective: to study the polymorphism of pro- and anti-inflammatory interleukin genes in children with acute bronchitis. Methods: The main group included 110 children aged 6-15 years with acute bronchitis. The control group included 163 healthy schoolchildren. DNA samples for the study were obtained from peripheral venous blood and epithelial cells scraped from the oral mucosa. Results: Significant differences were revealed between the group of children with bronchitis and control group according to the TNFA gene polymorphism. Significant differences in the main group depending on age are shown: predominance of the allele (-174)G of the il6 gene (p<0.05) at the age of 6 years, and among children aged 7-11 years, the allele (-174)С the il6 gene dominated (p=0.044). In a subgroup of patients under the age of 6 years, there was a decrease in the frequency of detection of the genotype (-174)C/C the il6 gene. Conclusions: The results obtained can become the basis for determining prognostic markers of recurrence of acute bronchitis with further development of individualized treatment and prevention programs.

Keywords:children; acute bronchitis; gene polymorphism; cytokines; TNFA; IL6; IL4; IL1B
 

Read the full article …

Citation link:
Pikuza O. I., Rizvanova F. F., Generalova E. V., Kravcova O. A. GENES POLYMORPHISM AND ACUTE BRONCHITIS IN CHILDREN // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2023. -№03. -С. 227-231 DOI 10.37882/2223–2966.2023.03.31
LEGAL INFORMATION:
Reproduction of materials is permitted only for non-commercial purposes with reference to the original publication. Protected by the laws of the Russian Federation. Any violations of the law are prosecuted.
© ООО "Научные технологии"

Terms Publications

Issues of the journals (Archive)

ECONOMICS AND LAW
HUMANITIES
NATURAL AND TECHNICAL SCIENCES
COGNITION

Серия - Natural and Technical Sciences