Dalgatova A. A. (Candidate of Medical Sciences,
Assistant of the Department of
pathological physiology FSBEI HE DSMU of
the Ministry of Health of Russia
)
Akaeva Kh. S. (Student of the 5th year of Dental
Faculty of FSBEI HE DSMU
of the Ministry of Health of Russia
)
Dalgatova M. A. (Student of the 5th year of Dental
Faculty of FSBEI HE DSMU
of the Ministry of Health of Russia
)
Batyrkhanova A. B. (Student of the 5th year of Dental
Faculty of FSBEI HE DSMU
of the Ministry of Health of Russia
)
Pirismailov A. I. (Student of the 5th year of Dental
Faculty of FSBEI HE DSMU
of the Ministry of Health of Russia
)
Davydova A. M. (Student of the 5th year of Dental
Faculty of FSBEI HE DSMU
of the Ministry of Health of Russia
)
| |
The article analyzes the role of human mitochondrial DNA population polymorphism in the formation of hereditary adaptation to extreme environmental conditions and predisposition to diseases. Mitochondrial DNA (mtDNA) genotyping is carried out using various methods, including modern high-throughput sequencing technologies. Phylogeographic studies make it possible to reconstruct the family tree of human mtDNA and to estimate the prevalence of characteristic haplotypes in various populations. Studies of the association of mtDNA polymorphisms with diseases are based on a comparison of the prevalence of haplotypes and individual mtDNA variants in patient groups with ethnically matched control samples.
Studies of mtDNA polymorphism in human populations from different geographic regions indicate that some haplotypes and individual mtDNA variants may play a role in population adaptation to high altitude conditions. Studies of associations of mtDNA polymorphisms with multifactorial diseases have revealed haplogroups and individual mtDNA polymorphisms that affect the risk of developing diseases and their complications depending on the population.
Keywords:mitochondrial DNA, genetic adaptation, hereditary predisposition
|
|
| |
|
Read the full article …
|
Citation link:
Dalgatova A. A., Akaeva K. S., Dalgatova M. A., Batyrkhanova A. B., Pirismailov A. I., Davydova A. M. MTDNA POLYMORPHISM AND ITS ROLE IN ADAPTATION TO ENVIRONMENTAL CONDITIONS AND PREDISPOSITION TO DISEASES // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2023. -№05. -С. 21-25 DOI 10.37882/2223-2966.2023.05.10 |
|
|
