Ruhlyada Nikolaj Nikolaevich (MD, PhD, Dr Med Sci, professor,
Head of the Department of Obstetrics and Gynecology, St. Petersburg State Pediatric Medical University Ministry of Health of the Russian Federation
)
Vinnikova Simona Viktorovna (Researcher of the Gynecology Department
State Medical Institution "St. Petersburg Research Institute" of Ambulance named after I. I. Janelidze
)
Tsechoyeva Leyla Shihmurzaeva (MD, PhD, Head of the Gynecological Department № 1 of the St. Petersburg Scientific Research Institute of Ambulance named after I. I. Janelidze. )
Luft Valery Matveyevich (MD, PhD, Dr Med Sci, Professor,
Head of the Clinical Nutrition Laboratory of the St. Petersburg Scientific Research Institute of Ambulance named after I. I. Dzhanelidze
)
Doronin Sergey Andreevich (Commercial Director of the laboratory "Explana". )
Polyakova Alyona Stanislavovna (resident of the St. Petersburg Scientific Research Institute of Ambulance named after I. I. Janelidze. )
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The subject of the study was 90 patients from the gynecological department No. 1 of the St. Petersburg Institute of Emergency Medicine named after I.I. Janelidze. We analyzed the medical history, interviewed and examined 50 women with undeveloped pregnancy and 40 women with progressive pregnancy. Retrospective and prospective studies of the state of the vaginal and intestinal microbiota were conducted using PCR - RV "Femoflor-16 and "Colonoflor-16" in the laboratory "Explana". Monitoring of the state of the vaginal and intestinal microbiota was carried out after 1 month. Women with undeveloped pregnancy were further subdivided into two subgroups: the first subgroup (Ia) consisted of 25 women without treatment correction, the second subgroup (Ib) consisted of 25 women with treatment correction with the addition of probiotic prebiotic and metabiotic.Keywords: undeveloped pregnancy, dysbiosis, prebiotic, metabiotic, microbiota.
The aim of the work was to assess the state of the vaginal and intestinal microbiota in women with undeveloped pregnancy before and after the correction using highly informative molecular genetic methods. As a result of the study, the following data were obtained: vaginal dysbiosis was diagnosed in 72% of women, colon dysbiosis in 54%, and a combination of dysbiosis of these media before the start of therapy was detected in 42% of women with an undeveloped pregnancy. After the therapy, normocenosis occurred in 72%, while in the Ia subgroup, vaginal normocenosis was detected in 56%, which is 2 times lower compared to the Ib subgroup – 88%, where two-stage therapy was performed. In the Ia subgroup, colon dysbiosis was detected in 64%, which is 5 times more than in the Ib subgroup – 12%.
Keywords:undeveloped pregnancy, dysbiosis, prebiotic, metabiotic, microbiota
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Citation link:
Ruhlyada N. N., Vinnikova S. V., Tsechoyeva L. S., Luft V. M., Doronin S. A., Polyakova A. S. VAGINAL AND INTESTINAL MICROBIOTA IN WOMEN WITH UNDEVELOPED PREGNANCY BEFORE AND AFTER CORRECTION OF STANDARD THERAPY // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2023. -№08/2. -С. 192-198 DOI 10.37882/2223-2966.2023.8-2.31 |
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