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ASSOCIATION OF FADS1 GENE RS174537 POLYMORPHISM WITH OBESITY IN THE YAKUT POPULATION

Pavlova Nadezhda Ivanovna  (PhD, Leading Researcher-Head of the Laboratory of Hereditary Pathology, Department of Molecular Genetics, Federal State Budgetary Scientific Institution "Yakut Scientific Center for Complex Medical Problems" )

Bochurov Alexey Alekseevich  (Junior Researcher, Laboratory of Hereditary Pathology, Department of Molecular Genetics Federal State Budgetary Scientific Institution "Yakut Scientific Center for Complex Medical Problems" )

Alekseev Vladislav Amirovich  (Junior Researcher, Arctic Medical Center, Department of Epidemiology of Chronic Non-Infectious Diseases Federal State Budgetary Scientific Institution "Yakut Scientific Center for Complex Medical Problems" )

Krylov Alexey Vasilievich  (Junior Researcher, Laboratory of Hereditary Pathology, Department of Molecular Genetics Federal State Budgetary Scientific Institution "Yakut Scientific Center for Complex Medical Problems" )

Sydykova Lyubov Akhmedovna  (Candidate of Medical Sciences, Associate Professor, Deputy Director for Clinical Work; Head of the Department of "Propaedeutic and Faculty Therapy with Endocrinology and Exercise Therapy" of the Medical Institute Federal State Autonomous Educational Institution of Higher Education "North-Eastern Federal University named after M.K. Ammosov" )

The study examined the distribution of frequencies of alleles and genotypes of the polymorphic gene FADS1 (rs174537) in a sample of Yakuts with normal body mass index, preobese and obese. A total of 450 DNA samples were studied, including a group with normal BMI (n=162), an obese group (n=184) and a pre-obese group (n=104). A high frequency of the T allele, which is unfavorable for diseases associated with lipid metabolism, has been established. A comparative analysis of the average body mass index depending on the genotype showed that in the group of obese people in carriers of the TT genotype (BMI = 33.6 ± 0.09) it was significantly higher (td=3.93, p=0.0001) than in carriers of the TG genotype (BMI=33.1±0.09).

Keywords:Obesity, FADS1, rs174537, PUFA
 

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Citation link:
Pavlova N. I., Bochurov A. A., Alekseev V. A., Krylov A. V., Sydykova L. A. ASSOCIATION OF FADS1 GENE RS174537 POLYMORPHISM WITH OBESITY IN THE YAKUT POPULATION // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2023. -№12. -С. 32-35 DOI 10.37882/2223-2966.2023.12.27
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