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TO STUDY THE RELATIONSHIP OF IMMUNE COMPLEXES CIRCULATING IN THE BLOOD WITH CYTOKINE NETWORK GENES IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS

Kazantseva Svetlana Rimovna  (Graduate student, Federal State Budgetary Educational Institution of Higher Education Bashkir State Medical University (Ufa) )

Nazarova Liliya Shamilevna  (Bashkir State Medical University (Ufa))

Danilko Ksenia Vladimirovna  (candidate of biological sciences, associate professor, Bashkir State Medical University (Ufa) )

Malievsky Viktor Arturovich  (Doctor of Medical Sciences, Professor, Bashkir State Medical University (Ufa) )

Annotation. The results of an analysis of associations of circulating immune complexes (CICs) in blood serum in 244 patients with juvenile idiopathic arthritis (JIA) with various combinations of polymorphic allelic variants of the immune response mediator genes TNFα rs1800629, IL-10 rs1800872 and IL-6 rs1800795 are presented. In the group of patients with JIA, genotypes of two-locus (IL-10*AA/IL-6*GC, TNFα*GA/IL-10*СA) and three-locus (TNFα*GG/IL-10*AA/IL-6*GC) models were established, significantly less common among patients with elevated levels of CEC. No associations have been established for individual loci. It is expected that in the course of further research, the results obtained will make it possible to predict and optimize the effectiveness of management of patients with JIA in accordance with its immune status and taking into account genetic characteristics.

Keywords:juvenile idiopathic arthritis, polymorphism of cytokine genes, circulating immune complexes, predictive medicine
 

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Citation link:
Kazantseva S. R., Nazarova L. S., Danilko K. V., Malievsky V. A. TO STUDY THE RELATIONSHIP OF IMMUNE COMPLEXES CIRCULATING IN THE BLOOD WITH CYTOKINE NETWORK GENES IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№04. -С. 18-22 DOI 10.37882/2223-2966.2024.04.15
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