Selezneva Alina Vladimirovna (Oncologist, graduate student at the Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia, Department of Oncology and Plastic Surgery)
Fatyanova Anastasia Sergeevna (Candidate of Medical Sciences, Associate Professor of the Department of Oncology, Radiotherapy and Reconstructive Surgery, Institute of Cluster Oncology named after. L.L. Levshin PMGMU named after. THEM. Sechenov (Sechenov University))
Reshetov Igor Vladimirovich (Academician of the Russian Academy of Sciences, Professor, Doctor of Medical Sciences, Head of the Department of Oncology, Radiotherapy and Reconstructive Surgery, Institute of Cluster Oncology named after. L.L. Levshin PMGMU named after. THEM. Sechenov (Sechenov University))
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Numerous publications have highlighted therapeutic advances, offering new treatment options for patients with non-small cell lung cancer (NSCLC) harboring rare molecular abnormalities. Goals and objectives: To analyze various clinical studies with rare types of molecular disorders, such as skipping of exon 14 (METex14), mutations and amplifications, overexpression of the HER2 gene, KIF5B-RET fusion, KRASG12C missense mutations found in NSCLC.
Materials and methods: Various clinical studies with rare molecular disorders NSCLC in which targeted therapy has been successfully used are reviewed. Results: Primary and secondary endpoint results for each clinical trial are presented, including objective response rate (ORR), progression-free survival (PFS), and overall survival (OS). Conclusions: The results obtained are a prerequisite for the development of new targeted agents, selective for rare molecular disorders, which will not only have a therapeutic effect, but will be able to cope with acquired resistance.
Keywords:Non-small cell lung cancer, targeted therapy, rare molecular disorders, missense mutations, gene fusions
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Citation link:
Selezneva A. V., Fatyanova A. S., Reshetov I. V. RARE MOLECULAR ABNORMALITIES IN NON-SMALL CELL LUNG CANCER AND WAYS TO SOLVE THEM IN THE FUTURE // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№11. -С. 250-253 DOI 10.37882/2223-2966.2024.11.34 |
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