Loyko Ekaterina Anatolyevna (Assistant
Kursk State Medical University (KSMU)
)
Nazarenko Peter Mikhailovich (Doctor of Medical Sciences, Professor, Head of the Department of Surgical Diseases No. 2
Kursk State Medical University (KSMU)
)
Nazarenko Dmitry Petrovich (Doctor of Medical Sciences, Professor
Kursk State Medical University (KSMU)
)
Kunakov Daniil Valerievich (Clinical Resident
Kursk State Medical University (KSMU)
)
Kunakova Alyona Evgenievna (Clinical Resident
Kursk State Medical University (KSMU)
)
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Obliterating atherosclerosis of the arteries of the lower extremities (OAANK) is a common disease leading to critical limb ischemia. Endothelial dysfunction (ED) plays a key role in its pathogenesis. Despite the availability of various methods of ED correction in OAANK, the optimal approach remains a matter of debate. The purpose of the review is to analyze modern strategies for ED correction in OAANK. The analysis of publications from the databases Pubmed, Scopus, RSCI for 2016-2023 was carried out. Pharmacological methods (statins, antithrombotics, Omacor, Cilostazol), endovascular interventions (balloon angioplasty and stenting), hybrid operations are considered. The effectiveness of an integrated approach combining drug therapy and surgical treatment is shown. The choice of the method depends on the stage of the disease, the location of the lesion, and the concomitant pathology. The prospects of hybrid operations, which allow achieving good results in multi-level lesions in high-risk patients, are noted. The need for further research to optimize the algorithms of a personalized approach to ED correction in OAANK is indicated. The data obtained can be used to improve clinical guidelines for the management of patients with OAANK.
Keywords:obliterating atherosclerosis, endothelial dysfunction, omacor, cilostazol, balloon angioplasty
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Citation link:
Loyko E. A., Nazarenko P. M., Nazarenko D. P., Kunakov D. V., Kunakova A. E. A MODERN APPROACH TO THE TREATMENT OF ENDOTHELIAL DYSFUNCTION IN OBLITERATING ATHEROSCLEROSIS OF THE ARTERIES OF THE LOWER EXTREMITIES (LITERATURE REVIEW) // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№12/2. -С. 86-91 DOI 10.37882/2223-2966.2024.12-2.14 |
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