Gamaeva Fatima Batalovna (PhD (Veterinary Sciences), Associate Professor, Department of Normal and Pathological Human Anatomy, Kabardino-Balkarian State University named after Kh.M. Berbekov, Kabardino-Balkarian Republic, Nalchik)
Musukaeva Anzhelika Batalovna (Assistant, Department of Normal and Pathological Human Anatomy,
Kabardino-Balkarian State University named after Kh.M. Berbekov, Kabardino-Balkarian Republic, Nalchik
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Khachetlova Karina Kazbekovna (Kabardino-Balkarian State University named after Kh.M. HM. Berbekova, Kabardino-Balkarian Republic, Nalchik)
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In modern medicine, the importance of plastic material for reconstructive interventions can hardly be overestimated. The most suitable material is cadaveric allograft, a tissue ideal in structure, hemodynamics, and organ compatibility. In this study, we investigated the issue of preimplantation processing of valve allografts for cardiac hock prosthetics. The main principle of processing is the complete removal of donor cellular elements with preservation of the connective tissue matrix intact. The aspects of aortic allograft strength and quality of its decellularization were studied on the model of 10 porcine aortic roots. A native porcine root served as a control, and a decellularization group and a decellularization group supplemented with supercritical CO2 treatment served as the study group. It was found out that decellularization according to the scheme “digitonin+EDTA” did not affect the allograft strength, and additional application of supercritical treatment in CO2 allowed to get rid of the remaining cellular elements - loci of further calcinosis.
Keywords:histology, histoarchitectonics, assessment of elastic strength characteristics, decellularization
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Citation link:
Gamaeva F. B., Musukaeva A. B., Khachetlova K. K. HISTOLOGICAL EVALUATION OF BIOLOGICAL TISSUES USED FOR HEART VALVE PROSTHESIS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№01. -С. 176-181 DOI 10.37882/2223-2966.2025.01.11 |
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