Fadiukhina Darya Ilyinichna (Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation (неофициально — Pirogov Russian National Research Medical University))
Proshina Marina Lvovna (Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation (неофициально — Pirogov Russian National Research Medical University))
Sashkina Tatiana Ivanovna (Doctor of Biological Sciences,
Professor of the Department of Pathophysiology and Clinical Pathophysiology at the institute of human biology and pathology
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation (неофициально — Pirogov Russian National Research Medical University)
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Lukashova Karina Arturovna (Assistant of the Department of Pathophysiology and Clinical Pathophysiology at the institute of human biology and pathology
Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation (неофициально — Pirogov Russian National Research Medical University)
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Cytokines play a key role in regulating inflammatory processes in alcoholic hepatitis. Understanding their functions is crucial for developing new therapeutic strategies. This study is aimed at a comprehensive analysis of the features of expression and interaction of pro- and anti-inflammatory cytokines at different stages of alcoholic liver damage. Methods of enzyme-linked immunosorbent assay, flow cytometry, and real-time PCR were used. The sample included 120 patients with acute alcoholic hepatitis and 80 patients with chronic alcoholic hepatitis. Results showed a statistically significant (p<0.01) increase in TNF-α, IL-6, and IL-8 levels in acute hepatitis, correlating with the degree of liver damage (r=0.68). In chronic hepatitis, an increase in IL-10 and TGF-β (p<0.05) was identified. The imbalance of pro- and anti-inflammatory cytokines may serve as a predictor of disease progression. The obtained data open prospects for the development of diagnostic biomarkers and targeted immunocorrection..
Keywords:cytokines, inflammation, alcoholic hepatitis, liver, immunoregulation.
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Citation link:
Fadiukhina D. I., Proshina M. L., Sashkina T. I., Lukashova K. A. THE ROLE OF CYTOKINES IN THE PATHOGENESIS OF ACUTE AND CHRONIC INFLAMMATION IN ACUTE AND CHRONIC ALCOHOLIC HEPATITIS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№02. -С. 225-229 DOI 10.37882/2223-2966.2025.02.32 |
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